Psilocybin extends cellular lifespan: new research

Researchers are hopeful. But it may be too soon to start hunting for a dealer.

If only they really looked like this.

Greetings! This is an exclusive paid subscriber benefit associated with my post, “Do magic mushrooms make you live longer?”

Here’s a quick review of a study from July 2025 by researchers from Emory University’s department of medicine showing how psilocybin extended lifespan in aging mice…and suggesting that it might work on you, too.

The paper, titled, “Psilocybin treatment extends cellular lifespan and improves survival of aged mice,” can be read in its entirety here. But unless you’re a scientist, it’s not a fun read. Instead, below are a well-known researcher’s detailed thoughts on the study, in plain-English, bullet-point form.

One longevity researcher’s review of the psilocybin study

Matt Kaeberlein is a respected University of Washington biologist and a longevity researcher with a reputation for not overstating the science — unlike a growing number of his colleagues in prestigious labs at Harvard (David Sinclair), MIT (Leonard Guarante) and Stanford (Andrew Huberman).